Piero di Cosimo, January 2, 1462–April 12, 1522, was an Italian Renaissance painter born and active in Florence. The son of Lorenzo di Piero d’Antonio, he entered Cosimo Rosselli’s workshop by 1480 and assisted him on the Sistine Chapel frescoes in Rome in 1481–1482.

He painted altarpieces, portraits, and mythological and allegorical scenes, including long spalliera panels for Florentine interiors. His work combined Florentine traditions with influences from Early Netherlandish painting and Leonardo da Vinci, and he was particularly noted for landscapes, animals, and narratives of humanity’s early history.

Piero spent his later career in Florence and died there in 1522. Andrea del Sarto was associated with his workshop according to Vasari. Major works are held by the Uffizi Gallery, National Gallery, Metropolitan Museum of Art, National Gallery of Art, and other European and North American collections.

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