Jan Sanders van Hemessen, c 1500–c 1566, was a Flemish painter born in Hemiksem near Antwerp. He was apprenticed to Hendrick van Cleve I in Antwerp in 1519–1520 and became a master in the city’s Guild of Saint Luke in 1524.

Van Hemessen maintained a successful Antwerp workshop and served as dean of the Guild of Saint Luke in 1548. He painted religious subjects, portraits, and moralizing scenes drawn from contemporary life, and he trained his daughter Catharina van Hemessen, who became a successful portrait painter.

His last dated paintings are from the 1550s, and the circumstances and place of his death remain uncertain. His works are held by institutions including the Kunsthistorisches Museum, Museo del Prado, State Hermitage Museum, Art Institute of Chicago, and Royal Museums of Fine Arts of Belgium.